Dissecting Two-Photon Microscopy

Dissecting Two-Photon Microscopy

Before the advent of microscopy, scientists such as Leonardo da Vinci had to surreptitiously dissect the human body to gather insights into its functional anatomy. Now, two-photon microscopy has further advanced our ability to peer into living tissues with minimal intervention. For instance, two-photon microscopy allows your window of vision to penetrate through a living mouse’s brain and marvel at a neuronal cell’s inner workings. Pan the microscope underneath the skin and you will see hair follicle stem cells dividing and regenerating in real-time. Over a tumor bulge, you can observe metastatic cancer cells migrating and invading blood vessels. The mechanics of this visual journey relies on two photons meeting each other at the same place at the right time.

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